Journal of Clinical Oncology: Early Release When an article is expected to have a substantial and immediate impact on clinical practice, the JCO may release it early by posting it on our web site. This decision is made by the Editors. When an article appears in print, it will be removed from this feature and grouped with other articles in an issue. The early release publication date appears below each title, followed by the article's unique Digital Object Identifier (DOI). To cite an article on this page, use the DOI. Do not use "In Press" to cite articles on this page, since they have already been published. To see an article, click its [PDF] link. To review multiple abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. The following articles have been released: EDITORIAL COMMENTS AND CONTROVERSIES ORIGINAL REPORTS Bone Marrow Transplantation Breast Cancer Clinical Trials Genitourinary Cancer Gynecologic Cancer Hematologic Malignancies Melanoma Supportive Care and Quality of Life Thoracic Oncology REVIEW ARTICLES SPECIAL ARTICLE EDITORIAL Prostate Cancer: Moving Forward by Reinventing the Wheel...But This Time It Is Round Derek Raghavan and Eric A. Klein * This is an editorial and, as such, does not have a full abstract. Tentatively scheduled for the 10/1/2008 print issue JCO published online July 14, 2008, 10.1200/JCO.2008.18.3145 [Abstract] [PDF] [top] COMMENTS AND CONTROVERSIES Neoadjuvant Treatment of Rectal Carcinoma: Assessment of Health Care Services by Physicians and Lay Persons Marko Kornmann, Doris Henne-Bruns, and Franz Porzsolt * This is a comments and controversies article and, as such, does not have a full abstract. Tentatively scheduled for the 10/10/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2008.16.2891 [Abstract] [PDF] [top] ORIGINAL REPORTS Bone Marrow Transplantation Allogeneic Hematopoietic Stem-Cell Transplantation for Chronic Lymphocytic Leukemia With 17p Deletion: A Retrospective European Group for Blood and Marrow Transplantation Analysis Johannes Schetelig, Anja van Biezen, Ronald Brand, Dolores Caballero, Rodrigo Martino, Maija Itala, José A. García-Marco, Liisa Volin, Norbert Schmitz, Rainer Schwerdtfeger, Arnold Ganser, Francesco Onida, Brigitte Mohr, Stephan Stilgenbauer, Martin Bornhäuser, Theo de Witte, and Peter Dreger Tentatively scheduled for the 10/20/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2008.16.2982 [Abstract] [PDF] [top] Breast Cancer Multicenter Study Using Paraffin-Embedded Tumor Tissue Testing PITX2 DNA Methylation As a Marker for Outcome Prediction in Tamoxifen-Treated, Node-Negative Breast Cancer Patients Nadia Harbeck, Inko Nimmrich, Arndt Hartmann, Jeffrey S. Ross, Tanja Cufer, Robert Grützmann, Glen Kristiansen, Angelo Paradiso, Oliver Hartmann, Astrid Margossian, John Martens, Ina Schwope, Antje Lukas, Volkmar Müller, Karin Milde-Langosch, Jörg Nährig, John Foekens, Sabine Maier, Manfred Schmitt, and Ralf Lesche Tentatively scheduled for the 10/20/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2007.14.1697 [Abstract] [PDF] Zoledronic Acid Prevents Bone Loss in Premenopausal Women Undergoing Adjuvant Chemotherapy for Early-Stage Breast Cancer Dawn L. Hershman, Donald J. McMahon, Katherine D. Crew, Serge Cremers, Dinaz Irani, Gina Cucchiara, Lois Brafman, and Elizabeth Shane Tentatively scheduled for the 10/10/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2008.16.4707 [Abstract] [PDF] Preoperative Staging of Large Primary Breast Cancer With [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Compared With Conventional Imaging Procedures David Fuster, Joan Duch, Pilar Paredes, Martín Velasco, Montserrat Muñoz, Gorane Santamaría, Montserrat Fontanillas, and Francesca Pons Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2008.17.1496 [Abstract] [PDF] An Ideal Prognostic Test for Estrogen Receptor–Positive Breast Cancer? Soonmyung Paik, Gong Tang, and Debora Fumagalli * This is an editorial and, as such, does not have a full abstract. Tentatively scheduled for the 9/1/2008 print issue JCO published online August 4, 2008, 10.1200/JCO.2008.16.7528 [Abstract] [PDF] Prognostic Utility of the 21-Gene Assay in Hormone Receptor–Positive Operable Breast Cancer Compared With Classical Clinicopathologic Features Lori J. Goldstein, Robert Gray, Sunil Badve, Barrett H. Childs, Carl Yoshizawa, Steve Rowley, Steven Shak, Frederick L. Baehner, Peter M. Ravdin, Nancy E. Davidson, George W. Sledge Jr, Edith A. Perez, Lawrence N. Shulman, Silvana Martino, and Joseph A. Sparano Tentatively scheduled for the 9/1/2008 print issue JCO published online August 4, 2008, 10.1200/JCO.2007.14.4501 [Abstract] [PDF] Concurrent Doxorubicin Plus Docetaxel Is Not More Effective Than Concurrent Doxorubicin Plus Cyclophosphamide in Operable Breast Cancer With 0 to 3 Positive Axillary Nodes: North American Breast Cancer Intergroup Trial E 2197 Lori J. Goldstein, Anne O'Neill, Joseph A. Sparano, Edith A. Perez, Lawrence N. Shulman, Silvana Martino, and Nancy E. Davidson Tentatively scheduled for the 9/1/2008 print issue JCO published online August 4, 2008, 10.1200/JCO.2008.16.7841 [Abstract] [PDF] Effect of Molecular Disease Subsets on Disease-Free Survival in Randomized Adjuvant Chemotherapy Trials for Estrogen-Receptor Positive Breast Cancer Lajos Pusztai, Kristine Broglio, Fabrice Andre, W. Fraser Symmans, Kenneth R. Hess, and Gabriel N. Hortobagyi Tentatively scheduled for the 10/1/2008 print issue JCO published online July 28, 2008, 10.1200/JCO.2008.17.2544 [Abstract] [PDF] Tumor Metabolism and Blood Flow Changes by Positron Emission Tomography: Relation to Survival in Patients Treated With Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Lisa K. Dunnwald, Julie R. Gralow, Georgiana K. Ellis, Robert B. Livingston, Hannah M. Linden, Jennifer M. Specht, Robert K. Doot, Thomas J. Lawton, William E. Barlow, Brenda F. Kurland, Erin K. Schubert, and David A. Mankoff Tentatively scheduled for the 9/20/2008 print issue JCO published online July 14, 2008, 10.1200/JCO.2007.15.4385 [Abstract] [PDF] Breast Cancer Onset in Twins and Women With Bilateral Disease Mikael Hartman, Per Hall, Gustaf Edgren, Marie Reilly, Linda Lindstrom, Paul Lichtenstein, Jaakko Kaprio, Axel Skytthe, Julian Peto, and Kamila Czene Tentatively scheduled for the 9/1/2008 print issue JCO published online June 30, 2008, 10.1200/JCO.2007.14.3198 [Abstract] [PDF] [top] Clinical Trials Analysis of Herpes Zoster Events Among Bortezomib-Treated Patients in the Phase III APEX Study Asher Chanan-Khan, Pieter Sonneveld, Michael W. Schuster, Edward A. Stadtmauer, Thierry Facon, Jean-Luc Harousseau, Dina Ben-Yehuda, Sagar Lonial, Hartmut Goldschmidt, Donna Reece, Rachel Neuwirth, Kenneth C. Anderson, and Paul G. Richardson Tentatively scheduled for the 10/10/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2007.14.9641 [Abstract] [PDF] Phase I-II Trial of Bortezomib Plus Oral Cyclophosphamide and Prednisone in Relapsed and Refractory Multiple Myeloma Donna E. Reece, Giovanni Piza Rodriguez, Christine Chen, Suzanne Trudel, Vishal Kukreti, Joseph Mikhael, Mariela Pantoja, Wei Xu, and A. Keith Stewart Tentatively scheduled for the 10/1/2008 print issue JCO published online July 21, 2008, 10.1200/JCO.2007.14.2372 [Abstract] [PDF] Lenalidomide Monotherapy in Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma Peter H. Wiernik, Izidore S. Lossos, Joseph M. Tuscano, Glen Justice, Julie M. Vose, Craig E. Cole, Wendy Lam, Kyle McBride, Kenton Wride, Dennis Pietronigro, Kenichi Takeshita, Annette Ervin-Haynes, Jerome B. Zeldis, and Thomas M. Habermann Tentatively scheduled for the 9/1/2008 print issue JCO published online July 7, 2008, 10.1200/JCO.2007.15.3429 [Abstract] [PDF] [top] Genitourinary Cancer Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven Gerhardt Attard, Alison H.M. Reid, Timothy A. Yap, Florence Raynaud, Mitch Dowsett, Sarah Settatree, Mary Barrett, Christopher Parker, Vanessa Martins, Elizabeth Folkerd, Jeremy Clark, Colin S. Cooper, Stan B. Kaye, David Dearnaley, Gloria Lee, and Johann S. de Bono Tentatively scheduled for the 10/1/2008 print issue JCO published online July 21, 2008, 10.1200/JCO.2007.15.9749 [Abstract] [PDF] [top] Gynecologic Cancer Phase II Study of Erlotinib in Recurrent or Metastatic Endometrial Cancer: NCIC IND-148 Amit M. Oza, Elizabeth A. Eisenhauer, Laurie Elit, Jean-Claude Cutz, Akira Sakurada, Ming S. Tsao, Paul J. Hoskins, Jim Biagi, Prafull Ghatage, John Mazurka, Diane Provencher, Naomi Dore, Janet Dancey, and Anthony Fyles Tentatively scheduled for the 9/10/2008 print issue JCO published online June 30, 2008, 10.1200/JCO.2007.15.8808 [Abstract] [PDF] [top] Hematologic Malignancies Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype Dimitri A. Breems, Wim L.J. Van Putten, Georgine E. De Greef, Shama L. Van Zelderen-Bhola, Klasien B.J. Gerssen-Schoorl, Clemens H.M. Mellink, Aggie Nieuwint, Martine Jotterand, Anne Hagemeijer, H. Berna Beverloo, and Bob Löwenberg Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2008.16.0259 [Abstract] [PDF] Addition of Rituximab to Standard Chemotherapy Improves the Survival of Both the Germinal Center B-Cell–Like and Non–Germinal Center B-Cell–Like Subtypes of Diffuse Large B-Cell Lymphoma Kai Fu, Dennis D. Weisenburger, William W.L. Choi, Kyle D. Perry, Lynette M. Smith, Xinlan Shi, Christine P. Hans, Timothy C. Greiner, Philip J. Bierman, R. Gregory Bociek, James O. Armitage, Wing C. Chan, and Julie M. Vose Tentatively scheduled for the 10/1/2008 print issue JCO published online July 28, 2008, 10.1200/JCO.2007.15.9277 [Abstract] [PDF] Follicular Lymphoma, Survival, and Rituximab: Is it Time to Declare Victory? Sandra J. Horning Tentatively scheduled for the 10/1/2008 print issue * This is an editorial and, as such, does not have a full abstract. JCO published online July 28, 2008, 10.1200/JCO.2008.16.1398 [Abstract] [PDF] Phase III Study of R-CVP Compared With Cyclophosphamide, Vincristine, and Prednisone Alone in Patients With Previously Untreated Advanced Follicular Lymphoma Robert Marcus, Kevin Imrie, Philippe Solal-Celigny, John V. Catalano, Anna Dmoszynska, João C. Raposo, Fritz C. Offner, José Gomez-Codina, Andrew Belch, David Cunningham, Elisabeth Wassner-Fritsch, and George Stein Tentatively scheduled for the 10/1/2008 print issue JCO published online July 28, 2008, 10.1200/JCO.2007.13.5376 [Abstract] [PDF] Del(6)(q22) and BCL6 Rearrangements in Primary CNS Lymphoma Are Indicators of an Aggressive Clinical Course Francois M. Cady, Brian Patrick O'Neill, Mark E. Law, Paul A. Decker, David M. Kurtz, Caterina Giannini, Alyx B. Porter, Paul J. Kurtin, Patrick B. Johnston, Ahmet Dogan, and Ellen D. Remstein Tentatively scheduled for the 10/1/2008 print issue JCO published online July 21, 2008, 10.1200/JCO.2008.16.1455 [Abstract] [PDF] Finding of Kinase Domain Mutations in Patients With Chronic Phase Chronic Myeloid Leukemia Responding to Imatinib May Identify Those at High Risk of Disease Progression Jamshid S. Khorashad, Hugues de Lavallade, Jane F. Apperley, Dragana Milojkovic, Alistair G. Reid, Marco Bua, Richard Szydlo, Eduardo Olavarria, Jaspal Kaeda, John M. Goldman, and David Marin Tentatively scheduled for the 10/1/2008 print issue JCO published online July 21, 2008, 10.1200/JCO.2008.16.9953 [Abstract] [PDF] International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes International T-Cell Lymphoma Project Tentatively scheduled for the 9/1/2008 print issue JCO published online July 14, 2008, 10.1200/JCO.2008.16.4558 [Abstract] [PDF] Phase II Multicenter Study of Bendamustine Plus Rituximab in Patients With Relapsed Indolent B-Cell and Mantle Cell Non-Hodgkin's Lymphoma K. Sue Robinson, Michael E. Williams, Richard H. van der Jagt, Philip Cohen, Jordan A. Herst, Anil Tulpule, Lee S. Schwartzberg, Bernard Lemieux, and Bruce D. Cheson Tentatively scheduled for the 9/20/2008 print issue JCO published online July 14, 2008, 10.1200/JCO.2008.17.0001 [Abstract] [PDF] Survival Patterns Among Lymphoma Patients With a Family History of Lymphoma Lesley A. Anderson, Ruth M. Pfeiffer, Joshua S. Rapkin, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Magnus Björkholm, Neil E. Caporaso, and Ola Landgren Tentatively scheduled for the 9/1/2008 print issue JCO published online July 7, 2008, 10.1200/JCO.2007.14.6571 [Abstract] [PDF] Allogeneic Hematopoietic Stem-Cell Transplantation for Myeloid Sarcoma: A Retrospective Study From the SFGM-TC Patrice Chevallier, Mohamad Mohty, Bruno Lioure, Gerard Michel, Nathalie Contentin, Eric Deconinck, Pierre Bordigoni, Jean-Paul Vernant, Mathilde Hunault, Stéphane Vigouroux, Didier Blaise, Reza Tabrizi, Agnes Buzyn, Gerard Socie, Mauricette Michallet, Christelle Volteau, and Jean-Luc Harousseau Tentatively scheduled for the 9/1/2008 print issue JCO published online July 7, 10.1200/JCO.2007.15.6315 [Abstract] [PDF] Five-Gene Model to Predict Survival in Mantle-Cell Lymphoma Using Frozen or Formalin-Fixed, Paraffin-Embedded Tissue Elena Hartmann, Verònica Fernàndez, Victor Moreno, Joan Valls, Luis Hernández, Francesc Bosch, Pau Abrisqueta, Wolfram Klapper, Martin Dreyling, Eva Hoster, Hans Konrad Müller-Hermelink, German Ott, Andreas Rosenwald, and Elías Campo Tentatively scheduled for the 9/1/2008 print issue JCO published online July 7, 10.1200/JCO.2007.12.0410 [Abstract] [PDF] Toward Optimization of Postremission Therapy for Residual Disease–Positive Patients With Acute Myeloid Leukemia Luca Maurillo, Francesco Buccisano, Maria Ilaria Del Principe, Giovanni Del Poeta, Alessandra Spagnoli, Paola Panetta, Emanuele Ammatuna, Benedetta Neri, Licia Ottaviani, Chiara Sarlo, Daniela Venditti, Micol Quaresima, Raffaella Cerretti, Manuela Rizzo, Paolo de Fabritiis, Francesco Lo Coco, William Arcese, Sergio Amadori, and Adriano Venditti Tentatively scheduled for the 9/1/2008 print issue JCO published online July 7, 10.1200/JCO.2007.15.9814 [Abstract] [PDF] Low-Dose Interleukin-2 Immunotherapy Does Not Improve Outcome of Patients Age 60 Years and Older With Acute Myeloid Leukemia in First Complete Remission: Cancer and Leukemia Group B Study 9720 Maria R. Baer, Stephen L. George, Michael A. Caligiuri, Ben L. Sanford, Sandra M. Bothun, Krzysztof Mrózek, Jonathan E. Kolitz, Bayard L. Powell, Joseph O. Moore, Richard M. Stone, John Anastasi, Clara D. Bloomfield, and Richard A. Larson Tentatively scheduled for the 9/1/2008 print issue JCO published online June 30, 2008, 10.1200/JCO.2008.17.0472 [Abstract] [PDF] Mutation of the Wilms' Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party Priya Virappane, Rosemary Gale, Robert Hills, Ioannis Kakkas, Karin Summers, Jane Stevens, Christopher Allen, Claire Green, Hilmar Quentmeier, Hans Drexler, Alan Burnett, David Linch, Dominique Bonnet, T. Andrew Lister, and Jude Fitzgibbon Tentatively scheduled for the 9/10/2008 print issue JCO published online June 30, 2008, 10.1200/JCO.2008.16.0333 [Abstract] [PDF] [top] Melanoma Microscopic Tumor Burden in Sentinel Lymph Nodes Predicts Synchronous Nonsentinel Lymph Node Involvement in Patients With Melanoma Jeffrey E. Gershenwald, Robert H.I. Andtbacka, Victor G. Prieto, Marcella M. Johnson, A. Hafeez Diwan, Jeffrey E. Lee, Paul F. Mansfield, Janice N. Cormier, Christopher W. Schacherer, and Merrick I. Ross Tentatively scheduled for the 9/10/2008 print issue JCO published online July 7, 2008, 10.1200/JCO.2007.15.4179 [Abstract] [PDF] [top] Supportive Care and Quality of Life Suicidal Thoughts and Actions in Cancer Patients: The Time for Exploration Is Now Timothy E. Quill * This is an editorial and, as such, does not have a full abstract. Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2008.18.3129 [Abstract] [PDF] Cancer and the Risk of Suicide in Older Americans Matthew Miller, Helen Mogun, Deborah Azrael, Katherine Hempstead, and Daniel H. Solomon Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2007.14.3990 [Abstract] [PDF] Incidence of Suicide in Persons With Cancer Stephanie Misono, Noel S. Weiss, Jesse R. Fann, Mary Redman, and Bevan Yueh Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2007.13.8941 [Abstract] [PDF] Better Off Dead: Suicidal Thoughts in Cancer Patients Jane Walker, Rachel A. Waters, Gordon Murray, Helen Swanson, Carina J. Hibberd, Robert W. Rush, Dawn J. Storey, Vanessa A. Strong, Marie T. Fallon, Lucy R. Wall, and Michael Sharpe Tentatively scheduled for the 10/10/2008 print issue JCO published online August 11, 2008, 10.1200/JCO.2007.11.8844 [Abstract] [PDF] Randomized Controlled Clinical Effectiveness Trial of Cognitive Behavior Therapy Compared With Treatment As Usual for Persistent Insomnia in Patients With Cancer Colin A. Espie, Leanne Fleming, James Cassidy, Leslie Samuel, Lynne M. Taylor, Craig A. White, Neil J. Douglas, Heather M. Engleman, Heidi-Louise Kelly, and James Paul Tentatively scheduled for the 10/1/2008 print issue JCO published online June 30, 2008, 10.1200/JCO.2007.13.9006 [Abstract] [PDF] [top] Thoracic Oncology Chemotherapy in Addition to Supportive Care Improves Survival in Advanced Non–Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 16 Randomized Controlled Trials NSCLC Meta-Analyses Collaborative Group Tentatively scheduled for the 10/1/2008 print issue JCO published online August 4, 2008, 10.1200/JCO.2008.17.7162 [Abstract] [PDF] Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 Chang-Qi Zhu, Gilda da Cunha Santos, Keyue Ding, Akira Sakurada, Jean-Claude Cutz, Ni Liu, Tong Zhang, Paula Marrano, Marlo Whitehead, Jeremy A. Squire, Suzanne Kamel-Reid, Lesley Seymour, Frances A. Shepherd, and Ming-Sound Tsao Tentatively scheduled for the 9/10/2008 print issue JCO published online July 14, 2008, 10.1200/JCO.2007.14.8924 [Abstract] [PDF] [Publisher's Note] [top] REVIEW ARTICLES Internal Mammary Nodes in Breast Cancer: Diagnosis and Implications for Patient Management—A Systematic Review Ronald C. Chen, Nancy U. Lin, Mehra Golshan, Jay R. Harris, and Jennifer R. Bellon Tentatively scheduled for the 10/20/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2008.17.4862 [Abstract] [PDF] Novel Insights in Chronic Lymphocytic Leukemia: Are We Getting Closer to Understanding the Pathogenesis of the Disease? Federico Caligaris-Cappio and Paolo Ghia Tentatively scheduled for the 9/20/2008 print issue JCO published online July 28, 2008, 10.1200/JCO.2007.15.4393 [Abstract] [PDF] [top] SPECIAL ARTICLE Urgent Need for a New Staging System in Advanced Colorectal Cancer Graeme J. Poston, Joan Figueras, Felice Giuliante, Gennaro Nuzzo, Alberto F. Sobrero, Jean-Francois Gigot, Bernard Nordlinger, Rene Adam, Thomas Gruenberger, Michael A. Choti, Anton J. Bilchik, Eric J.D. Van Cutsem, Jy-Ming Chiang, and Michael I. D'Angelica Tentatively scheduled for the 10/10/2008 print issue JCO published online August 18, 2008, 10.1200/JCO.2008.17.6453 [Abstract] [PDF] [top]